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Use of complex lipids as stabilizing additions for digestion enzyme mixtures pharmaceutical compositions
Use of complex lipids as stabilizing additions for digestion enzyme mixtures pharmaceutical compositions
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机译:复杂脂质作为消化酶混合物药物组合物的稳定添加剂的用途
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摘要
Use of complex lipids is claimed for stabilising an aqueous formulation of digestive enzymes lipases and proteases against loss of lipolytic activity caused by the action of moisture. The enzyme mixtures are for the production of aqueous solutions for continuous introduction into the gastrointestinal tract using a tube. Also claimed are (1) the stabilised water-soluble pharmaceutical formulations obtained; and (2) a kit for the production of the sterile aqueous formulation for administration by tube comprising: (a) a sterile, solid pharmaceutical preparation of digestive enzymes; and (b) a sterile aqueous solvent containing water and optionally physiologically acceptable salts and adjuvants: where (a) or (b) also contains sufficient complex lipid to stabilise the product.
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