CHINA CLAY WITH CONTINUOUS RELEASE FOR ORAL ADMINISTRATION TO RUMINANTS, BEING ACTIVE FOR PROLONGATED PREVENTION FROM CONTAMINATION OF ANIMALS WITH ADULTS OR LARVAE OF HELMINTHS, ECTOPARASITIC INSECTS AND MITES

摘要

A sustained release bolus formulation comprising a prophylactically effective amount of a compound selected from the group consisting of LL-F28249 alpha, 23- / O-methyloxime / LL-F28249 alpha and derivatives thereof, which provides a method of protecting ruminants for extended periods against nematode infestation, acaricides and endo- and ectoparasitic insects and which during this time may also eliminate the initial population of parasites present in the treatment. The invention also relates to a method for the systematic control of infestations of ruminants by ectoparasitic insects by oral administration of a sustained-release bolus to said animals. Bolus contains an insecticidally effective amount of LL-F28249 alpha, 23- (O-methyloxime), or LL-F28249 alpha or derivatives thereof, which are continuously released into the rumen of a treated animal in a systemically effective amount of LL-F28249 alpha, 23- (O-methyloxime) / LL -F28249 alpha or derivatives thereof