ANALOG OF L-ARGININE EXHIBITING INHIBITION ACTIVITY TO NO SYNTHASE, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF

摘要

In the present invention there are disclosed L-arginine derivatives of the general formula I, in which A represents hydrogen, alkyl containing 1 to 6 carbon atoms or NOi2, E represents oxygen or a covalent bond, n is zero or an integer ranging from 1 through 12 and Ri1 and Ri2 represent independently on each other a branched or straight alkyl group containing 1 to 6 carbon atoms or Ri1 and Ri2 form together with a nitrogen atom to which they are attached a ring of the formula b wherein Xi1 represents an alkylene or alkenylene chain having 1 to 2 carbon atoms, Xi2 represents methylene or ?CH= and X represents an oxygen, sulfur or nitrogen atom, an imino group, an alkylimino group having 1 to 6 carbon atoms or an ethylene radical, and their pharmaceutically acceptable salts. These derivatives are useful for preparing medicaments intended for treating pathologies of central and peripheral nervous system, pathological dysfunction of digestive and urinary tract of inflammatory or non-inflammatory type and pathologies connected with cardiovascular or bronchopulmonary systems. There are also described processes for preparing the derivatives, medicaments, as well as use of these derivatives for preparing medicaments based on these substances.