DERIVATIVES OF CLOSTRIDIUM TOXINS BEING CAPABLE OF MODIFYING FUNCTIONS OF PROLIFERATIVE SENSORIC AFFERENT NEURONE

摘要

The invention relates to an agent specific for peripheral sensory afferents. The agent may inhibit the transmission of signals between a primary sensory afferent and a projection neutron by controlling the release of at least one neurotransmitter or neuromodulator from the primary sensory afferent. The agent may be used in or as a pharmaceutical for the treatment of pain, particularly chronic pain.