ESSENTIALLY DETERMINED PURIFIED SURFACE ANTIGEN OF PROTEIN NATURE NEISSERIA AND FRAGMENT OF THIS ANTIGEN

摘要

A highly conserved immunologically accessible antigen on the surface of Neisseria meningitidis organisms, as well as immunotherapeutic, prophylactic and diagnostic compositions and methods for treating, preventing and diagnosing diseases caused by Neisseria meningitidis, are claimed. In addition, the objects of the invention are a proteinase-resistant Neisseria meningitidis surface protein having a molecular weight of about 22 kDa, the corresponding nucleotide and amino acid sequences isolated from it (SEQ ID NO: 1, NO: 3, NO: 5 and NO: 7; SEQ ID NO: 2, NO: 4, NO: 6 and NO: 8), recombinant DNA methods for producing 22 kDa Neisseria meningitidis surface protein and antibodies that bind to 22 kDa Neisseria meningitidis surface protein. The international application was published with the report about international search.