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Monocrystalline particles of iron-oxide for application in medical diagnosis and therapy
Monocrystalline particles of iron-oxide for application in medical diagnosis and therapy
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机译:氧化铁单晶颗粒在医学诊断和治疗中的应用
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摘要
The invention relates to nanocrystalline magnetic particles consisting of a magnetic iron oxide core composed of Fe3O4, gamma -Fe2O3 or mixtures thereof and of a shell chemisorbed onto this core, to processes for the production of these particles and to the use thereof in medical diagnosis and therapy. The magnetic particles according to the invention are distinguished by the shell material being composed of natural or synthetic glycosaminoglycans and their derivatives with molecular weights of 500 Da to 250,000 Da and being optionally covalently crosslinked by suitable crosslinkers and/or modified by specific additives.
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机译:本发明涉及由由Fe 3 O 4,γ-Fe2 O 3或它们的混合物组成的磁性氧化铁核以及化学吸附到该核上的壳组成的纳米晶体磁性颗粒,涉及这些颗粒的生产方法及其在医学诊断和治疗中的用途。治疗。根据本发明的磁性颗粒的特征在于,壳材料由天然或合成的糖胺聚糖及其分子量为500 Da至250,000 Da的衍生物组成,并任选地通过合适的交联剂进行共价交联和/或通过特定的添加剂改性。
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