USE OF PERSISTENT FREE-RADICALS IN MAGNETIC RESONANCE IMAGING.

摘要

PCT No. PCT/EP92/01793 Sec. 371 Date Mar. 18, 1994 Sec. 102(e) Date Mar. 18, 1994 PCT Filed Aug. 6, 1992 PCT Pub. No. WO93/02711 PCT Pub. Date Feb. 18, 1993.The present invention provides the use of a persistent pi -system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising pi -system of said radical comprises at least one homo or heterocyclic ring, said radical being other than the chloranil semiquinone anion radical or a trityl radical. Also provided are magnetic resonance imaging contrast media containing and methods using such radicals.