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process for purification of cyclosporin a and / or related cyclosporinen a cyclosporin containing rohextrakt using chromatographic method with silica gel as adsorbent
process for purification of cyclosporin a and / or related cyclosporinen a cyclosporin containing rohextrakt using chromatographic method with silica gel as adsorbent
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机译:硅胶为吸附剂的色谱法纯化环孢菌素a和/或相关环孢菌素的方法
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摘要
The present invention relates to a novel chromatographic process which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the simulated moving bed method (SMB). The cyclosporin A obtained corresponds both to the quality requirements of USP XXIII and of EUROPEAN PHARMACOPOEIA, 2nd Edition 1995.
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