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PEPTIDE/PROTEIN MODIFIED WITH INSERTION OF COMPLETE OR PARTIAL CARBOXY TERMINAL PEPTIDE UNIT INTO A NON CRITICAL REGION
PEPTIDE/PROTEIN MODIFIED WITH INSERTION OF COMPLETE OR PARTIAL CARBOXY TERMINAL PEPTIDE UNIT INTO A NON CRITICAL REGION
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机译:将完整或部分羧基末端肽单元插入非关键区域的修饰的肽/蛋白质
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摘要
"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides to alter their clearance patterns. "Complete" CTP units have the amino acid sequence found at positions 112-118 to position 145 of the beta -subunit of human chorionic gonadotropin; "partial" CTP units are missing at least one amino acid in the region of position 118-145 inclusive. Variants of these CTP units contain 1-5 conservative amino acid substitutions which do not destroy activity. Suitable peptides or proteins which may be modified in this manner include various hormones and cytokines.
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