METHOD FOR ACHIEVING A SYNERGISTIC THERAPEUTIC EFFECT WITH THERAPEUTIC COMPOSITIONS CONTAINED BY AT LEAST TWO THERAPEUTIC AGENTS SELECTED FROM A RENIN INHIBITOR, AN ANGIOTENSIN I CONVERSATION ENZYME INHIBITOR AND AN ANGIOTENSIN II ANTAGONIST

摘要

Compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, synergistic compositions comprising amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotensin I converting enzyme inhibitor and an angiotensin II antagonist, which inhibitors and antagonists are present in amounts sufficient to cause synergistic therapeutic effects such as lowering blood pressure and treating congestive heart failure in a mammal. Further, methods for achieving synergistic therapeutic effects, such as lowering blood pressure and treating congestive heart failure in a mammal, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotension I converting enzyme inhibitor and an angiotensin II antagonist, in amounts sufficient to achieve a synergistic therapeutic effect.