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ANALOGS OF ACIDIC FIBROBLAST GROWTH FACTOR HAVING ENHANCED STABILITY AND BIOLOGICAL ACTIVITY
ANALOGS OF ACIDIC FIBROBLAST GROWTH FACTOR HAVING ENHANCED STABILITY AND BIOLOGICAL ACTIVITY
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机译:具有增强的稳定性和生物活性的酸性成纤维细胞生长因子类似物
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摘要
Analogs of proteins in the FGF family are provided in accordance with the present invention. These analogs are more stable than the corresponding naturally occurring proteins. Enhanced stability may be achieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in an identified loop-forming region in the amino acid sequence of the protein. The analogs of the present invention are especially useful in therapeutic applications.
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