首页>
外国专利>
DERIVATIVE OF 2-AMINOTHIAZOLE OR 2-AMINOOXAZOLE AND 5-AMINO- -1,2,4-OXADIAZOLE OR 5-AMINO-1,2,4-OXATHIAZOLE, A PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
DERIVATIVE OF 2-AMINOTHIAZOLE OR 2-AMINOOXAZOLE AND 5-AMINO- -1,2,4-OXADIAZOLE OR 5-AMINO-1,2,4-OXATHIAZOLE, A PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
The invention relates to compounds of formula: IMAGE I in which: A is selected from O or S; B is selected from C or N; Z1 is selected from C1-C4 alkylene or phenylene; Z2 is C1-C4 alkylene; W is NR1R2, in which R1 is selected from H or C1-C4 alkyl and R2 is selected from H, C1-C4 alkyl, CONQ1Q2 or CSNQ1Q2 in which Q1 and Q2 are independently selected from H or C1-C4 alkyl, SO2Q3 or COQ3 in which Q3 is C1-C4 alkyl, COOQ4 in which Q4 is selected from C1-C4 alkyl or benzyl, or R1 and R2 taken together with N form a saturated heterocycle, or W is selected from C1-C4 alkoxy or thioalkoxy, CONQ1Q2 or CSNQ1Q2, pyridyl, imidazolyl or COOQ5 in which Q5 is C1-C5 alkyl; R3 is not present when B is N, or is H, C1-C8 alkyl or halogen; Ar1 is selected from optionally substituted phenyl, thienyl, furyl, indolyl, naphthyl or benzyl or Ar1 and R3 taken together form a phenylalkylene group; Ar2 is selected from pyrimidinyl, quinolyl, isoquinolyl, indolyl, isoindolyl or pyridyl, optionally substituted; as well as their salts.
展开▼
机译:本发明涉及式:I的化合物,其中:A选自O或S; B选自C或N; Z1选自C1-C4亚烷基或亚苯基; Z2为C1-C4亚烷基; W是NR1R2,其中R1选自H或C1-C4烷基,R2选自H,C1-C4烷基,CONQ1Q2或CSNQ1Q2,其中Q1和Q2独立地选自H或C1-C4烷基,SO2Q3或COQ3其中Q3是C1-C4烷基,COOQ4,其中Q4选自C1-C4烷基或苄基,或R1和R2与N一起形成饱和杂环,或W选自C1-C4烷氧基或硫代烷氧基,CONQ1Q2或CSNQ1Q2,吡啶基,咪唑基或COOQ5,其中Q5为C1-C5烷基;当B为N或为H,C1-C8烷基或卤素时,R3不存在; Ar1选自任选取代的苯基,噻吩基,呋喃基,吲哚基,萘基或苄基,或Ar1和R3一起形成亚苯基。 Ar 2选自嘧啶基,喹啉基,异喹啉基,吲哚基,异吲哚基或吡啶基,任选地被取代;以及它们的盐。
展开▼