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Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases.
Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases.
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机译:用于治疗急慢性炎症的药物。
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摘要
The use of a compound of the formula I CHEM or a pharmaceutically acceptable acid addition salt thereof, wherein R3 is 1-piperidyl, 1-(3-indolyl)ethyl, (C1-C4)-alkyl, phenyl, benzyl, 1-(1-phenylethyl) or monosubstituted benzyl wherein the substituent is chloro, fluoro, methyl or methoxy and said substituent is on the aromatic ring; R4 is bicycloÄ2.2.1Ühept-2-yl or a group of the formula II CHEM wherein Y is hydrogen, fluoro or chloro; and X is hydrogen, fluoro, chloro, methoxy, trifluoromethyl, cyano, carboxy, methylcarbamoyl, dimethyl-carbamoyl or carbo(C1-C4)alkoxy; for the manufacture of a medicament for inhibiting phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF).
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机译:式I 的化合物或其药学上可接受的酸加成盐的用途,其中R 3为1-哌啶基,1-(3-吲哚基)乙基,(C1-C4)-烷基,苯基,苄基,1-(1-苯乙基)或单取代的苄基,其中取代基是氯,氟,甲基或甲氧基,并且所述取代基在芳环上; R 4是双环2.2.1Ü庚-2-基或式II 的基团,其中Y是氢,氟或氯; X是氢,氟,氯,甲氧基,三氟甲基,氰基,羧基,甲基氨基甲酰基,二甲基氨基甲酰基或碳(C1-C4)烷氧基;用于制造用于抑制IV型磷酸二酯酶(PDE)或产生肿瘤坏死因子(TNF)的药物。
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