首页> 外国专利> new 2 - aminothiazol - fused 2 - aminoindans and 2 - (aminotetralins (basic) - n - (substituted and basic) - n, n - disubstituted derivatives of 2,6 - diamino - thiazolo (4,5 - f) indan and 2.7 - di - amino - thiazolo (4,5-g) tetralin

new 2 - aminothiazol - fused 2 - aminoindans and 2 - (aminotetralins (basic) - n - (substituted and basic) - n, n - disubstituted derivatives of 2,6 - diamino - thiazolo (4,5 - f) indan and 2.7 - di - amino - thiazolo (4,5-g) tetralin

机译:新的2-氨基噻唑-稠合的2-氨基茚满和2-(氨基四氢萘(碱性)-n-(取代的和碱性的)-n,n-2,6-二氨基-噻唑洛(4,5-f)茚满和2.7的二取代衍生物-二氨基-噻唑罗(4,5-g)四氢萘

摘要

The invention relates to 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins having general formula (1): wherein R1 and R2, which may be identical or different, are selected from the group consisting of a hydrogen atom, alkyl or haloalkyl groups of 1 to 7 carbon atoms, (alkyl)cycloalkyl groups of 3 to 7 carbon atoms, alkenyl or alkynyl groups of 3 to 6 carbon atoms, arylalkyl having 1 to 3 carbon atoms in the alkyl moiety, while the aryl nucleus may be substituted; and n and m are 1 or 2; and the enantiomers and the acid addition salts thereof, pharmaceutical compositions containing them and their use in the preparation of medicaments having an effect on the dopaminergic system of the central nervous system and/or the circulation.
机译:本发明涉及具有通式(1)的2-氨基噻唑稠合的2-氨基茚满和2-氨基四氢化萘:其中R 1和R 2可以相同或不同,选自氢原子,烷基或卤代烷基。 1至7个碳原子,3至7个碳原子的(烷基)环烷基,3至6个碳原子的烯基或炔基,在烷基部分中具有1至3个碳原子的芳基烷基,而芳基核可以被取代; n和m为1或2;及其对映体及其酸加成盐,包含它们的药物组合物及其在制备对中枢神经系统和/或循环的多巴胺能系统有影响的药物中的用途。

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