Novel fused pyrrolecarboxa mides a new glass of gaba brain receptor ligands

摘要

The present invention encompasses structures of the formula I: or the pharmaceutically acceptable non-toxic salts thereof wherein: G represents where Q is aryl substituents optionally mono or disubstituted with hydroxy or halogen; T is halogen, hydrogen, hydroxyl, amino or alkoxy having 1-6 carbon atoms; W is oxygen, nitrogen, sulfur, or optionally substituted methylene; X is hydrogen, hydroxyl, or alkyl; Z is an organic or inorganic substituent optionally forming a ring with subtituents on Q; independently represent optionally substituted carbon chains; wherein k, m, and n are independently 0, or an integer of from 1-3 R3, R4, R5, and R6 are the same or different and represent organic or inorganic substituents. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.