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ANTI-PROLIFERATIVE AND ANTI-INFLAMMATORY COMPOUNDS: 5- OR 6-DEOXYHEXOSE MONOSACCHARIDES, IN 5 OR 6-POSITIONS, OF A SATURATED NITROGENIC HETEROCYCLES BONDED BY THE NITROGEN ATOM
ANTI-PROLIFERATIVE AND ANTI-INFLAMMATORY COMPOUNDS: 5- OR 6-DEOXYHEXOSE MONOSACCHARIDES, IN 5 OR 6-POSITIONS, OF A SATURATED NITROGENIC HETEROCYCLES BONDED BY THE NITROGEN ATOM
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机译:抗增殖和抗炎化合物:由氮原子键合的饱和氮原子杂环化合物在5或6位上的5或6-脱氧己糖单糖
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摘要
The compounds of this invention are 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom. The saturated nitrogen-containing heterocycle substituent is shown by the following formula: IMAGE where X is CH2, NH or O; and n ranges from 3-6. These hexose monosaccharides may also be ethereally substituted at least one other position. The compounds exhibit anti-proliferative and anti-inflammatory activity. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treating inflammatory and/or autoimmune disorders employing the compounds are disclosed.
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