5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE AND RELATED COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT

摘要

The present invention relates to tetrahydroquinolines and related compounds. More particularly, the present invention relates to 5-amino-5,6,7,8-tetrahydroquinolines of the formula CHEM wherein X-Y is a group of the formula CHEM wherein R is hydrogen, alkyl, alkenyl, alkynyl, or arylalkyl, or a group of the formula CHEM wherein R1 is hydrogen, alkyl or arylalkyl; R2 and R3 are independently hydrogen, alkyl, arylalkyl, diarylalkyl, cycloalkenylalkyl, alkoxy, arylalkoxy, or alkanoyl; R2 and R3 taken together with the nitrogen atom to which they are attached form a group of the formula CHEM wherein p is 0 or 1, a group of the formula CHEM wherein Z is O, S, or a group of the formula NR6 wherein R6 is hydrogen, alkyl, or arylalkyl; R4 is hydrogen, alkyl or arylalkyl; R5 is hydrogen, alkyl or arylalkyl; and m is 0, 1, or 2, and n is 1 or 2; or geometrical and optical isomers thereof, or a pharmaceutically acceptable salt thereof, which are useful for relieving memory dysfunction, The invention relates further to a process for the preparation of these compounds and their use as medicaments.