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PHARMACEUTICAL COMPOSITION FOR LOCATION-SPECIFIC DELIVERY OF BLOOD CLOTH-RESOLVING PROTEINS
PHARMACEUTICAL COMPOSITION FOR LOCATION-SPECIFIC DELIVERY OF BLOOD CLOTH-RESOLVING PROTEINS
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机译:用于特定位置的血液脱脂蛋白质递送的药物组合物
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摘要
A pharmaceutical composition for the treatment of blood clots as well as a diagnostic composition for the detection of blood clots are described, which composition comprises a liposome or another biodegradable colloidal carrier, which has a plasminogen bonded to it as targeting device and has a plasminogen activator, in particular a tissue-type plasminogen activator (tPA), as clot-dissolving protein, or a diagnostic agent. A method is also described for the preparation of a composition having blood clot-decomposing properties, in which method: a) plasminogen is bound to liposomes, the affinity of the plasminogen for fibrin being essentially maintained; and b) a plasminogen activator is incorporated in the liposomes, under conditions such that the interaction of the plasminogen with the plasminogen activator is reduced. A method is also described for bonding plasminogen to liposomes, a substantially purified plasminogen being used as starting material.
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