DISPOSAL OF CHEMICAL COMPOUNDS, USED TO TREAT LIPOSOLUBLE COMPOUNDS, OF BIOLOGICAL MATERIALS BY EXTRACTION WITH NATURAL OILS OR SYNTHETIC SUBSTITUTES THEREOF.

摘要

A procedure for the elimination of chemical compounds used to treat lipid soluble compounds from uid biological materials, selected from the group consisting of blood plasma, Fraction I, Fraction II, Fraction III, Fraction IV-1, Fraction IV-4, Fraction V , Fraction VI, fibronectin, antihemophilic factor, prealbumin, retinol binding protein, albumin, alpha-globulins, beta-globulins, gamma-globulins, antithrombin III, prothrombin, plasminogen, fibrinogen, Factor XIII, immunoglobulin G, immunoglobulin A, immunoglobulin M, immunoglobulin D and immunoglobulin E, plasmin inhibitor, prothrombin, thrombin, antithrombin, Factor V, Factor VII, Factor VIII, Factor IX and Factor X, containing said chemical compounds used to treat lipid soluble compounds, said compound being chemical used to treat lipid soluble compounds, a solvent that attenuates viruses with a selected high point of inamination or between the group consisting of di- or trialkylphosphates containing substituted or unsubstituted, branched or unbranched alkyl groups containing from 3 to 30 carbon atoms and mixtures thereof, in a proportion comprised between 0.01 and 100 mg / ml and a detergent, said method comprising contacting said biological materials containing said chemical compounds used to treat lipid soluble compounds, with an effective proportion of a naturally occurring oil extracted from a plant or of an animal or a synthetic compound with a similar chemical structure, the oil being non-flammable, non-explosive, compatible with blood derivatives and biological materials administered parenterally and pharmaceutically and physiologically tolerable by a human, in which the oil is contained in a proportion of 5 to 50% by weight, based on the weight of the biological materials used, the agitation of the mixture resulting, the separation of an upper phase and a lower phase by sedimentation or centrifugation and the decantation of the upper phase.