C1q receptor, encoding gene and application in host defense enhancement

摘要

Nucleic and amino acid sequences for a novel cell surface transmembrane glycoprotein designated ClqRP are taught. A method by which the nucleic acid sequence encoding ClqRP may be used to modulate the role of the immune system is also described. Transgenic animals created with heterologous DNA sequence encoding ClqRP are described as well as antibodies directed against the ClqRP protein. A method of hybridization for ClqRP nucleic acid using oligonucleotide probes based on the ClqRP nucleic acid sequence and methods for detecting a hybrid probe:target ClqRP duplex are also taught including a kit for such detection.