首页> 外国专利> Quinoline-2(1h)-one and dihydroquinoline-2(1h)-one derivatives as ligands of 5-ht, 5-ht2 and 5-ht1-like receptors

Quinoline-2(1h)-one and dihydroquinoline-2(1h)-one derivatives as ligands of 5-ht, 5-ht2 and 5-ht1-like receptors

机译:喹啉2(1h)-one和二氢喹啉2(1h)-one衍生物作为5-ht,5-ht2和5-ht1类受体的配体

摘要

The invention concerns compounds of formula (I) in which o---/o represents a single or double bond; G represents (G) in position 3 or 4; m = 2 to 4; Z represents a nitrogen atom or a -CH- group; R1 and R2 each represent independently of each other, a hydrogen or halogen atom, an amino, hydroxy, nitro, cyano, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, trifluoromethoxy, -COOH, -COOR4, -CONH2, -CONHR4, -CONR4R5, -SR4, -SO2R4, -NHCOR4, -NHSO2R4, -N(R4)2 group; R3 represents a hydrogen atom, a (C1-C4) alkyl, -(CH2)pOH, -(CH2)pNH2, -(CH2)nCOOH, -(CH2)nCOOR4, -(CH2)nCN, -(CH2)n-tetrazolyl, -(CH2)nCONH2, -(CH2)nCONHOH, -(CH2)pSH, (CH2)nSO3H, -(CH2)nSO2NH2, -(CH2)nSO2NHR4, -(CH2)nSO2NR4R5, -(CH2)nCONHR4, -(CH2)nCONR4R5, -(CH2)pNHSO2R4, -(CH2)pNHCOR4, -(CH2)pOCOR4 group; R4 and R5 are each a (C1-C4) alkyl group; n = 1 to 4; p = 2 to 4; and A represents a benzo group optionally substituted or not. The invention is applicable in therapeutics.
机译:本发明涉及式(I)的化合物,其中 --- 代表单键或双键; G代表3或4位的(G); m = 2至4; Z代表氮原子或-CH-基团; R 1和R 2彼此独立地表示氢或卤素原子,氨基,羟基,硝基,氰基,(C 1 -C 6)烷基,(C 1 -C 6)烷氧基,三氟甲基,三氟甲氧基,-COOH,-COOR 4- CONH2,-CONHR4,-CONR4R5,-SR4,-SO2R4,-NHCOR4,-NHSO2R4,-N(R4)2基团; R3代表氢原子,(C1-C4)烷基,-(CH2)pOH,-(CH2)pNH2,-(CH2)nCOOH,-(CH2)nCOOR4,-(CH2)nCN,-(CH2)n-四唑基,-(CH2)nCONH2,-(CH2)nCONHOH,-(CH2)pSH,(CH2)nSO3H,-(CH2)nSO2NH2,-(CH2)nSO2NHR4,-(CH2)nSO2NR4R5,-(CH2)nCONHR4,- (CH2)nCONR4R5,-(CH2)pNHSO2R4,-(CH2)pNHCOR4,-(CH2)pOCOR4基团; R 4和R 5各自为(C 1 -C 4)烷基。 n = 1至4; p = 2至4; A表示任选被取代或未被取代的苯并基。本发明可用于治疗。

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