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Ion-channel forming amphiphilic peptides having n-terminal modifications
Ion-channel forming amphiphilic peptides having n-terminal modifications
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机译:具有n末端修饰的形成离子通道的两亲肽
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摘要
An N-terminal substituted peptide or protein having formula (1). X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is formula (2), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and virally-infected cells.
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