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CONJUGATES OF MINOR GROOVE DNA BINDERS WITH ANTISENSE OLIGONUCLEOTIDES
CONJUGATES OF MINOR GROOVE DNA BINDERS WITH ANTISENSE OLIGONUCLEOTIDES
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机译:小槽DNA结合物与反义寡核苷酸的结合
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摘要
Compositions of antisense oligonucleotides conjugated to peptides of a plurality of N-methylpyrrolecarboxamides linked by peptide bonds is provided. The compositions form stable hybridization complexes with DNA and can be used for any purpose which involves hybridizing an oligonucleotide to a DNA molecule, such as in antisense procedures. A method for enhancing oligonucleotide binding to a target is also provided. The method involves the step of hybridizing the target DNA with an oligonucleotide-peptide composition.
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