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METHOD AND DEVICE FOR APPLYING HYPERTHERMIA TO ENHANCE DRUG PERFUSION AND EFFICACY OF SUBSEQUENT LIGHT THERAPY
METHOD AND DEVICE FOR APPLYING HYPERTHERMIA TO ENHANCE DRUG PERFUSION AND EFFICACY OF SUBSEQUENT LIGHT THERAPY
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机译:应用热疗提高随后光疗的药物灌注和功效的方法和装置
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摘要
A method and apparatus for applying heat to a treatment site prior to effecting photodynamic therapy. The perfusion of a drug into abnormal tissue in a tumor (12) is enhanced by heating the treatment site at which the tumor is disposed using a heat source (26) mounted on a fixture (20, 34) separate from a light source (28) on a probe used to effect the photodynamic therapy. Alternatively, the heat source and light source may comprise different types of light emitting diodes (LEDs) arranged in an array on a probe (14) disposed at the treatment site. Also mounted on the fixture is a temperature sensor (30), which produces a signal indicative of the temperature at the treatment sensor (30), which produces a signal indicative of the temperature at the treatment site. In response to this signal, a controller (24/36) controls the heat source to prevent vascular damage. In addition to enhancing the perfusion of a photoreactive agent into the treatment site, heating the tissue at the site prior to initiating the PDT greatly enhances the efficacy of this treatment.
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