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PURINE INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 (GSK3)
PURINE INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 (GSK3)
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机译:糖原合酶激酶3(GSK3)的嘌呤抑制剂
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摘要
Compounds of formula (1) wherein R1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R2 is hydroxy, amino, or lower alkoxy; R3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.
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机译:式(1)的化合物,其中R 1是烷基,被0-3个选自低级烷基,卤素,羟基,低级烷氧基,氨基,低级烷基-氨基和硝基的取代基取代的烷基,环烷基,芳基,芳烷基,杂芳基或杂芳烷基; R 2是羟基,氨基或低级烷氧基; R3为H,低级烷基,低级酰基,低级烷氧基-酰基或氨基-酰基; R4为H或低级烷基;及其药学上可接受的盐和酯;是GSK3的有效抑制剂。
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