A NOVEL TRANSCRIPTION FACTOR EXPRESSED IN CYCLING CELLS, NUCLEIC ACID MOLECULES ENCODING SAID TRANSCRIPTION FACTOR AND ITS PROMOTER REGION AND USES THEREOF

摘要

A novel transcription factor and its encoding nucleic acid molecules, as well as its consensus DNA binding motif are disclosed. The invention also discloses the DNA promoter region of the novel transcription factor that drives ubiquitous expression of genes in cycling cells, but is silent in resting cells, and its use in gene therapeutic strategies for the treatment of, e.g., malignancies. Furthermore, monoclonal antibodies reacting with said transcription factor and their use for the detection of cycling cells are disclosed.