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TRANSGENIC MOUSE EXPRESSING HUMAN CD4 AND FUSIN (CXCR4)
TRANSGENIC MOUSE EXPRESSING HUMAN CD4 AND FUSIN (CXCR4)
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机译:表达人类CD4和融合蛋白(CXCR4)的转基因小鼠
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摘要
This invention provides a transgenic mouse capable of expressing at least two cell surface membrane proteins of human T lymphocytes, transgenes for use in production of the transgenic mouse, and a method for producing the transgenic mouse using the transgenes. The cell surface membrane proteins of human T lymphocytes are associated particularly with human immunodeficiency virus (HIV) infection, and are preferably human CD4 and fusin (CXCR4). The transgenic mouse is able to inherit to its progeny a trait of expressing the cell surface membrane proteins of human T lymphocytes, thus being useful for an animal model for HIV infection and AIDS.
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