Provided, among other things, is an isolated nucleic acid encoding a GABA-gated chloride channel having: (a) a nucleic acid including a sequence encoding a protein sequence of SEQ ID 3, SEQ ID 6 or SEQ ID 8, or a sequence having at least about 85 % sequence identity with SEQ ID3, SEQ ID 6 or SEQ ID 8; or (b) a nucleic acid that hybridizes with a nucleic acid encoding a protein sequence of SEQ ID 3, SEQ ID 6 or SEQ ID 8 or the complementary sequence to SEQ ID 3, SEQ ID 6 or SEQ ID 8, under stringent conditions; or (c) a nucleic acid that hybridizes with a nucleic acid having a sequence of SEQ ID 1, SEQ ID 4 or SEQ ID 7 or the complementary sequence to SEQ ID 1, SEQ ID 4 or SEQ ID 7, under stringent conditions; or (d) a nucleic acid has at least about 85 % sequence identity with the coding region of SEQ ID 1, SEQ ID 4 or SEQ ID 7.
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机译:除其他事项外,提供了编码具有GABA门控氯离子通道的分离的核酸,其具有:(a)包含编码SEQ ID 3,SEQ ID 6或SEQ ID 8的蛋白质序列的序列的核酸,或具有与SEQ ID 3,SEQ ID 6或SEQ ID 8至少约85%的序列同一性; (b)在严格条件下与编码SEQ ID 3,SEQ ID 6或SEQ ID 8的蛋白质序列或与SEQ ID 3,SEQ ID 6或SEQ ID 8的互补序列的核酸杂交的核酸; (c)在严格条件下与具有SEQ ID 1,SEQ ID 4或SEQ ID 7的序列或与SEQ ID 1,SEQ ID 4或SEQ ID 7的互补序列的核酸杂交的核酸;或(d)核酸与SEQ ID 1,SEQ ID 4或SEQ ID 7的编码区具有至少约85%的序列同一性。
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