BLOCKING INTERCELLULAR INTERACTIONS WITH CD43 CHIMERIC MOLECULES.

摘要

Disclosed is a method of inhibiting an interaction between a first and a second cell in a mammal. The method involves providing a soluble chimeric molecule which includes: a) a cell targeting molecule which is capable of specifically recognizing and binding to a molecule on the surface of the first cell covalently bonded to b) a CD43 extracellular domain bearing a net negative charge at physiological pH; and administering the chimeric molecule to the mammal to inhibit the intercellular interaction. Also disclosed are useful CD43-containing chimeric molecules.