PEPTIDE FRAGMENTS OF TISSUE FACTOR AND THEIR USE FOR TREATMENT AND PREVENTION OF CLOTTING DISORDERS

摘要

Peptide reagents and compositions thereof which reduce blood clotting initiated by the ternary complex of tissue factor (TF), FVIIa and FXa. The peptides have the amino acid sequences Thr-Leu-Tyr-Tyr-Trp-Arg-Ala-Ser-Ser-Thr (SEQ. ID. NO: 3) and Ile-Ile-Thr-Tyr-Arg-Lys-Gly-Ser-Ser-Thr (SEQ. ID. NO: 2).