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PREPARATION OF TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES
PREPARATION OF TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES
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机译:通过主胺制备他克索和十六烷
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摘要
The invention relates to a process for converting Taxol A, B and C to Taxol primary amine which can then be easily and efficiently converted to Taxol A or docetaxel, thereby significantly increasing the yield of these products from biomass. The method includes the removal of the amide from the side-chain with Schwartz's reagent to form an imine, followed by the hydrolysis of the imine to the primary amine. The primary amine can then be converted to Taxol A or docetaxel. New Taxol imine compounds and primary amine salts have been formed by this process.
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