N,N-DIMETHYL-2-(5-(2-OXO-1,3-OXAZOLIDINE-4-YL-METHYL)-1H-INDO- -LE-3-YL)-ETHYLAMINE, ITS PHYSIOLOGICALLY ACCEPTABLE SALT OR SOLVATE, METHOD OF ITS SYNTHESIS, DRUG USED AS AN AGONIST OF '5-HT₁-LIKE' RECEPTOR IN MAMMALS, METHOD OF DRUG AGENT PREPARING

摘要

FIELD: organic chemistry. SUBSTANCE: product: N,N-dimethyl-2-[5-(2-oxo-1,3-oxazolidine-4-yl-methyl)-1H-indo- -le-3-yl] -ethylamine of the formula (I) HT001 as its (S)- or (R)-form or their mixture or its physiologically acceptable salt or solvate. Method of synthesis involves interaction of compound of the formula (II) HT₁ with compound of the formula (III) or its carbonyl-protected form where L - suitable group that can be removed or protective amino-group that under conditions in situ can be converted to dimethylamino-group, or group where and -NR¹R², - methyl. Invention proposes a drug agent containing an effective amount of compound (I) R¹, method of its preparing, prophylaxis and treatment of mammals required for intake of agonist of "5-R²-like" receptor by administration of compound (I) -HT₁- in mammal organism at the dose 0.01-5 mg/kg body weight as measured for free base. In part, proposed drug can be used for migraine treatment. EFFECT: improved method of synthesis, enhanced effectiveness of prophylaxis and treatment. 14 cl