N-(4,5-DIHYDROXY- AND 4,5,8-TRIHYDROXY-9,10-DIHYDRO-9,10-DI- -OXO-2-ANTHRACENYL)CARBONYL-AMINO ACIDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

摘要

FIELD: organic chemistry. SUBSTANCE: product: N-[(4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-di- -oxo-2-anthracenyl)carbonyl] -amino acids of the formula given in description where X means H or OH; R means C₁-C₆-alkyl or C₁-C₆-alkyl-thio-C₁-C₆-alkyl, their enantiomers and racemic mixtures and their pharmaceutical salts exhibiting antiinflammatory activity. Invention relates to also a method their synthesis and pharmaceutical composition showing inhibitory effect on human leukocyte elastase activity and formation of free radicals. EFFECT: improved method of synthesis, enhanced effectiveness of composition. 6 cl, 1 tbl