Functionalised polymer supports for solid-phase synthesis

摘要

Polymer supports are claimed which have a methacryloyl group of formula P-Z-CO-C(=CR1R2)-CR3R4-X (I). P = a natural, semisynthetic or synthetic polymer support; R1, R2 = H, alkyl, aryl or halogen; R3, R4 = H, alkyl or aryl; X = group suitable for coupling chosen from OH, halo, sulphonate, phosphonate, azido, amino, alkoxy, thioether, amido or acyloxy (derived from carboxylic acid); Z = alkylene, NH, NR or O; R is not defined. Also claimed is a process for synthesising optionally protected peptides, oligosaccharides, glycopeptides, nucleotides or proteins, by cleaving a compound (I; X = alkoxy or COR) by reaction with a nucleophile, or by cleaving a compound (I; X = acyloxy) with a catalytic amount of Pd. R = organic residue, and COR = is especially the optionally protected residue of an aminoacid, peptide or glycopeptide; alkoxy = residue of an alcohol, especially the optionally protected residue of a saccharide or nucleotide.