Inhibition of mineral entry with the aid of phosphorylated and similar polyanionic peptides

摘要

A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure:poly (X)_m(Y)_nwhereeach X independently is aspartate, glutamate, glutamine, asparagine, or anionic derivatives of these amino acids, or phosphoserine,each Y independently is a phosphorylated amino acid such as phosphoserine, phosphohomoserine, phosphotyrosine, phosphothreonine, phosphoglutamine, phosphoasparagine, or mixtures of these residues,m is 2 to 150,n is 1 to 3, andn + m is ≧ 5, andsalts of these peptides.