substituted (pyridinylamino) - benzisoxazole and benzisothiazole, a process for their manufacture and their use as medicines

摘要

There are disclosed various compounds of the formula below, CHEM R1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, cycloalkylloweralkyl, loweralkoxyloweralkyl, hydroxyloweralkyl, aminoloweralkyl, mono- or di-loweralkylaminoloweralkyl, formyl, loweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl, mono-or di-aryl-substituted loweralkyl, arylcarbonylloweralkyl, aryloxyloweralkyl, or CHEM -X is O or S; W is hydrogen, halogen, hydroxy, loweralkoxy, arylloweralkoxy, nitro, trifluoromethyl or CHEM where R3 is hydrogen, loweralkyl or arylloweralkyl, and R4 is loweralkyl or arylloweralkyl; or alternatively the group CHEM as a whole is CHEM R5 being hydrogen, loweralkyl, aryl or arylloweralkyl; and Z is hydrogen, halogen, loweralkyl, nitro or amino; which are useful as antidepressants.