POLYPEPTIDES COMPRISING PROTEIN GAX DOMAINS INVOLVED IN TRANSCRIPTION REPRESSION AND / OR INTERACTING WITH OTHER PROTEINS, CORRESPONDING NUCLEIC ACIDS AND USES THEREOF

摘要

The invention concerns polynucleotides comprising GAX domains, involved in the biological activity of GAX. In particular it may concern domains involved in the interaction of GAX with other molecules or domains responsible for a biological activity. The invention also concerns the chimerical molecules comprising a functional domain of GAX. It further concerns the use of GAX for repressing the expression of genes, and the use of compounds inhibiting the interaction of GAX with certain cell partners for modulating the activity of GAX, It also concerns a method for screening and/or identifying cell partners of GAX.