Molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a protein produced by P. falciparum at the sporozoite stage and in the hepatocytes

摘要

The invention relates to a polypeptide characterized in that it contains at least one peptide sequence carrying one or several epitopes characteristic of a protein produced at the sporozoite stage and in the hepatocytes infected by P. falciparum, this sequence comprising a sequence of from 10 amino acids to the maximal number of amino acids of the following peptide chain sequence:PPGlu-Phe-Arg-Val- Ser-Thr-Ser- Asp-Thr-Pro-Gly-Gly-Asn-Glu-Ser-Ser-Ser-Ala-Ser-Pro-Asn-Leu- Ser-Gly-Ala- Arg-Glu-Lys-Lys-Asp-Glu-Lys-Glu-Ala-Ser-Glu-Gln-Gly-Glu-Glu- Ser-His-Lys- Lys-Glu-Asn-Ser-Gln-Glu-Ser-Ala-Asn-Gly-Lys-Asp-Asp-Val-Lys- Glu-Glu-Lys- Lys-Thr-Asn-Glu-Lys-Lys-Asp-Asp-Gly-Lys-Thr-Asp-Lys-Val-Gln- Glu-Lys-Val- Leu-Glu-Lys-Ser-Pro-Lys-Glu-Phe.PPIt also relates to the use of these polypeptides, as well as the nucleotide sequences coding for these polypeptides, in methods of in vitro diagnosis of malaria on a biological sample derived from the individual in whom the disease is to be detected.