Vitamin D3 analogs useful for reversing the photodamage in sun- exposed skin

摘要

The use of compounds of formula I as topical agents to combat the disorders of the skin, produced by photodamage, which disorders include wrinkling, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein R.sub.1 is hydrogen, hydroxy or fluorine, R.sub.2 is hydrogen or halogen and A is --C|C--, -- C═C-- or - -CH.sub.2 --CH.sub.2 --, provided that when A is --CH.sub. 2 --CH.sub.2 - - , R.sub.2 is hydrogen.