The invention relates to biologically active substances coated with a coating composition containing at least one substance selected from the group consisting of hardened vegetable fats and oils, hardened animal fats and oils, fatty acid esters and phospholipids and an enzyme and/or enzyme activator where the outermost surface portion of the coating layer contains substantially no enzyme and/or enzyme activator. The invention materials exhibit excellent protection in the rumen of ruminant animals and allow for the dissolution in the post-abomasum lower digestive organs of the ruminant.
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