N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system

摘要

##STR1## wherein R.sup.1 is H, alkyl or cycloalkyl of 1 to 6 carbon atoms;PPR.sup.2 is H, alkyl of 1 to 6 carbon atoms, cyano, halo, nitro, amino or mono or dialkylamino in which the alkyl groups have 1 to 6 carbon atoms;PPR.sup.3 is H or alkyl of 1 to 6 carbon atoms;PPn is 1 to 5PPand R.sup.4 and R.sup.5 taken with the nitrogen atom to which they are attached are polymethylene of 4 to 6 carbon atoms, morpholino, pyrrolidin- 2-on-1-yl, or a piperazin-1-yl moiety in the 4-position of which is H, alkyl of 1 to 6 carbon atoms or unsubstituted or substituted pyrimidinyl, pyridinyl, or pyrazinyl wherein the substituents are alkyl of 1 to 6 carbon atoms, alkoxyl of 1 to 6 carbon atoms, halo, cyano, nitro or trifluoromethyl and the pharmaceutically acceptable salts, hydrates and solvates thereof are M. sub.1 receptor agonists useful in treatment of dementias involving the cholinergic system.