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L-amp;bgr;-dioxolane uridine analog administration for treating Epstein- Barr virus infection
L-amp;bgr;-dioxolane uridine analog administration for treating Epstein- Barr virus infection
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机译:L-&bgr-二氧戊环尿苷类似物给药用于治疗爱泼斯坦-巴尔病毒感染
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摘要
The present invention relates to the discovery that certain &bgr;- L- dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV infections in humans.
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