首页> 外国专利> Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers which comprise pyrimidine analogs, triple helix complexes formed thereby and oligomers used in their formation

Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers which comprise pyrimidine analogs, triple helix complexes formed thereby and oligomers used in their formation

机译:使用包含嘧啶类似物的核苷低聚物形成单链核酸的三螺旋复合物,由此形成的三螺旋复合物及其形成中使用的低聚物

摘要

Methods of detecting, recognizing or inhibiting or altering expression of a target sequence of a single stranded nucleic acid having any combination of purine and pyrimidine nucleosides by formation of triple helix complexes in conjunction with Second and Third Strands which comprise optionally covalently linked Oligomers are provided.
机译:提供了通过与包含任选地共价连接的寡聚物的第二和第三链一起形成三螺旋复合物来检测,识别或抑制或改变具有嘌呤和嘧啶核苷的任何组合的单链核酸的靶序列的表达的方法。

著录项

  • 公开/公告号US5834185A

    专利类型

  • 公开/公告日1998-11-10

    原文格式PDF

  • 申请/专利权人 JOHNS HOPKINS UNIVERSITY;

    申请/专利号US19940342647

  • 发明设计人 PAUL ON-PONG TSO;TINA LYNN TRAPANE;

    申请日1994-11-21

  • 分类号C12Q1/68;

  • 国家 US

  • 入库时间 2022-08-22 02:38:14

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