General formula (I)In the formula (R1, R1, nitrophenyl, R2, R3, and R4 each represent a lower alkyl group), an ocular tissue peripheral circulation improving agent that contains a salt that is acceptable as a useful ingredient in the ocular tissue peripheral circulation improving agent, especially the optic nerve papillary blood flow Therapeutic agents such as good medicine, choroidal blood flow improving agent, retinal blood flow improving agent, and visual field stenosis with normal tension glaucoma based on these actions, optic neuropathy, retinopathy and retinal degeneration disease.
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