Crystal Characteristic (R (* on R and * on R))2 (4 fluoro phenyl) and dihydroxy 5 (1 methylethyl) 3 phenyl 4 ((phenylamino) carbonyl) 1H pyrrole 1 heptane Acid hemikarushiumu salt (atorvastatin)

摘要

There are described novel crystalline forms of ÄR-(R*,R*)Ü-2-(4-fluorophenyl)- beta , delta -dihydroxy-5-(1-methylethyl)-3-phenyl-4-Ä(phenylamino)carbonylÜ-1H-pyr role-l-heptanoic acid hemi calcium salt designated Form II and Form IV which are characterized by their X-ray powder diffraction and/or solid state NMR, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia and hypercholesterolemia.