ADVERSE EFFECT IMPROVER FOR ADRENAL CORTICAL STEROID COMPRISING LACTIC ACID BACTERIUM COMPETITIVE CULTURE PRODUCT AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To obtain a therapeutic agent for adverse effect symptoms of adrenal cortical steroid, safe and usable for a long period of time, capable of suppressing inhibitory actions immune function and inhibitory actions and inhibitory action on granulation tissue proliferation as adverse effects of adrenal cortical steroid, by including a lactic acid bacterium culture product. ;SOLUTION: This agent comprises a lactic acid bacterium competitive culture product as an active ingredient. Preferably a lactic acid bacterium containing at least one kind of Lactobacillus lactis and a streptococcus (e.g. B. bulgaricus A) in each group and a strain obtained by subjecting plural lactic acid bacterium groups different in the groups in each group to primary culture at 37°C on the average for 120 hours, joining the culture products of the groups and subjecting the joined culture products to second culture is used as the lactic acid bacterium. An extract derived from a microbial cell solution obtained by grinding and extracting a metabolic product during the culture and a microbial cell is used as the active ingredient. An effective amount for treating an atopic patient is preferably 0.01-50 wt.% based on 1 g of a base.;COPYRIGHT: (C)1999,JPO