The angiotensin conversion enzyme inhibiter which designates the remedy of the heart vascular disease as purpose, the aldosterone antagonist of the side effect reduction tonnage and combination medical therapy of the diuretic

摘要

Combinations of an ACE inhibitor, an aldosterone receptor antagonist and a diuretic, i.e., "triple therapy" combinations, are described for use in treatment of circulatory disorders. of particular interest are triple therapies using captopril or enalapril co-administered with a low-dose of spironolactone and furosemide. This triple therapy would be particularly useful to treat or prevent the progression of congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.