USAGE OF TETRAHYDROFOLATE OF NATURAL STEROISOMERIC FORM IN PRODUCTION OF AGENT SUITABLE FOR EXERTING INFLUENCE ON HOMOCYSTENINE-LEVEL, ESPECIALLY SUITABLE FOR ASSISTING REMETHYLATION OF HOMOCYSTENINE

摘要

PROBLEM TO BE SOLVED: To provide a method for using a tetrahydrofolate of a natural stereoisomeric form in an agent suitable for exerting an influence on the homocysteine- level, especially suitable for assisting the remethylation of the homocysteine. SOLUTION: 5-Formyl-(6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrafolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6S)-tetrahydrofolic acid, 10-formyl-(6S)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid or (6S)-tetrahydrofolic acid or its pharmaceutical compatible salt is used as a tetrahydrofolate. The clinical use region of the compounds is all abnormalities of homocysteine-level, especially prophylaxis and treatment of cardiac-/ circulatory diseases and spinal canal-deficiency.