4 - acyloxy - 2 - manufacturing method null of azetidinone

摘要

PURPOSE:To obtain a compound useful as a synthetic intermediate for penem or carbapenem compounds without using mercury salts causing environmental pollution by reacting a 2-azetidinone derivative with a copper compound in the presence of an organic carboxylic acid. CONSTITUTION:A 2-azetidinone derivative expressed by formula I (OR is protected OH; X is alkyl or aromatic group) is reacted with a copper compound. In the process, a free or salt type organic carboxylic acid as an acyl group supply source is contained in the reaction mixture to carry out the reaction and afford the objective substance expressed by formula II (Y is acyl). The organic carboxylic acid is an aliphatic or aromatic carboxylic acid. The copper compound which is a copper salt (cupric acetate) of the organic carboxylic acid serves also as the acyl group supply source. The copper compound is used in an amount of =0.5 equiv. based on the compound expressed by formula I.