MANUFACTURE OF AT LEAST TWO-PHASE SOLID BLENDED MEDICINE SHAPE AND THIS BLENDED MEDICINE SHAPE

摘要

PROBLEM TO BE SOLVED: To manufacture a solid blended medicine shape in a large variation width by housing a solid preparation in a plastic material, and containing a single active substance in melt and/or the preparation when a medicine shape is molded from the melt composed of a high molecular weight binding agent. SOLUTION: Melt composed of a high molecular weight binding agent (for example, alkyl cellulose, hydroxyalkyl cellulose or the like) and an-active substance is molded. When this is molded, a single solid preparation containing the active substance is put in a plastic material. In a molding process, metal mold rollers 1 and 2 are rotated in the opposite direction, and a strand 3 from an extruder is composed of an active substance containing high molecular weight binding agent, and is sent into the two rollers 1 and 2 in the arrow direction. At the same time, melt composed of an active substance containing high molecular weight binding agent B is sent into a recess of the roller 1 from a supply device 4. Since the roller 1 is cooled, the melt immediately coagulates. A tablet is punched from the strand 3 by opposite directional rotation of the rollers 1 and 2.